# Spironolactone Lowers Blood Pressure in Small Post-Stroke Trial

Preliminary REDUCE findings show better blood-pressure control; the trial did not test whether the drug prevents another stroke.

By Will Langan | 24X7 News
Published: 2026-11-07T21:04:18.309Z
Updated: 2026-11-07T21:08:06.972Z
Section: Health
Format: News
Canonical: https://24x7news.us/articles/reduce-stroke-spironolactone-blood-pressure-trial-november-7-2026

Adding spironolactone to usual care lowered home blood pressure in a small randomized study of stroke survivors, according to preliminary results released November 7 at the American Heart Association’s Scientific Sessions in Chicago.

The REDUCE trial enrolled 160 adults with uncontrolled blood pressure after either a clot-caused or bleeding stroke at five U.S. medical centers. At three months, systolic pressure averaged nearly 8 mm Hg lower with the added medication. The blood-pressure target below 130/80 mm Hg was reached by 52% of that group, compared with 30% receiving usual care.

The trial did not establish whether spironolactone prevents another stroke or heart attack. Enrollment stopped below the planned 200 participants, about 15% lacked three-month measurements, and treatment assignments were known to participants and researchers.

Serious adverse-event rates were similar. Elevated potassium occurred in about 4% receiving spironolactone. The findings remain preliminary: they were presented as a conference abstract, rather than a peer-reviewed full manuscript.

## Sources
- American Heart Association — REDUCE results, released November 7, 2026, 2 p.m. Central: https://newsroom.heart.org/news/can-a-low-cost-diuretic-medication-help-to-lower-blood-pressure-after-a-stroke
- Image — CDC PHIL 14867, Yvonne Green, 2012; public domain, available free: https://wwwn.cdc.gov/phil/Details.aspx?pid=14867
- Image reuse terms — CDC agency materials: https://www.cdc.gov/other/agencymaterials.html